2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Opioid Receptor

Opioid Receptor

Opioid Receptor

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Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Isoform Specific Products:

Opioid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W046349
    N,N-didesmethyl AH 7921
    N,N-didesmethyl AH 7921 is structurally categorized as an opioid metabolite and is a metabolite of AH 7921.
    N,N-didesmethyl AH 7921
  • HY-108229S
    6β-Naltrexol-d3
    		Antagonist
    6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit.
    6β-Naltrexol-d<sub>3</sub>
  • HY-126063
    ICI-204448 free acid
    ICI-204448 free acid is a κ-opioid agonist with limited access to the CNS, ICI-204448 free acid can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes.
    ICI-204448 free acid
  • HY-U00420
    Opioid receptor modulator 1
    		Modulator
    Opioid receptor modulator 1 is a opioid receptor modulator extracted from patent WO2014072809A2, Compound RA11 in EXAMPLE 7.
    Opioid receptor modulator 1
  • HY-N13293
    Isopaynantheine
    		Control
    Isopaynantheine (3-Isopaynantheine), an alkaloid, is an opioid. Isopaynantheine has antinociceptive activity in mice.
    Isopaynantheine
  • HY-114861
    Nor-6α-Oxycodol
    Nor-6α-Oxycodol is structurally similar to known opioids and is a metabolite of Oxycodone.
    Nor-6α-Oxycodol
  • HY-17609S
    Difelikefalin-d5
    		Agonist
    Difelikefalin-d5 (CR-845-d5) is deuterium labeled Difelikefalin. Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.
    Difelikefalin-d<sub>5</sub>
  • HY-120045
    DuP 747
    		Agonist
    DuP 747 is a select opioid kappa agonist analgesic amine.
    DuP 747
  • HY-19467
    SCH 486757
    		Agonist
    SCH 486757 is an orally effective pain peptide receptor (NOP) agonist. SCH 486757 can be used for the study of cough.
    SCH 486757
  • HY-167842
    22-Thiocyanatosalvinorin A
    		Agonist
    22-Thiocyanatosalvinorin A (RB-64) is a potent and selective kappa-opioid receptor agonist with an EC50 of 0.077 nM.
    22-Thiocyanatosalvinorin A
  • HY-P2199
    SNF 9007
    SNF 9007 is a cholecystokinin analog. SNF 9007 induces analgesia by acting on δ-1, δ-2, and μ opioid receptors in the mouse brain.
    SNF 9007
  • HY-172149
    Naltrindole 5′-isothiocyanate
    		Antagonist
    Naltrindole 5′-isothiocyanate (5'-NTII) is a non-selective delta opioid receptor antagonist that can antagonize the analgesic effects induced by DSLET (HY-P1332) without affecting the analgesic effects induced by DPDPE (HY-P1334).
    Naltrindole 5′-isothiocyanate
  • HY-121854
    Bromadoline
    Bromadoline is a utopioid with antinociceptive activity in rodents.
    Bromadoline
  • HY-162570
    Volazocine
    Volazocine is an opioid benzomorphane derivative with potential analgesic activity.
    Volazocine
  • HY-W725295
    1-(5-Fluoropentyl)-1H-indazole-3-carboxylic acid
    1-(5-Fluoropentyl)-1H-indazole-3-carboxylic acid is structurally similar to known synthetic cannabinoid metabolites.
    1-(5-Fluoropentyl)-1H-indazole-3-carboxylic acid
  • HY-123142
    RX809055AX
    		Antagonist
    RX 809055AX is a potent long lasting opioid antagonist with selectivity towards at mu and delta receptors.
    RX809055AX
  • HY-A0118S1
    Naloxegol-13C,d2
    		Antagonist
    Naloxegol-13C,d2 (NKTR-118-13C,d2) is 13C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.
    Naloxegol-<sup>13</sup>C<sub>,d<sub>2</sub>
  • HY-W725190
    Piperidylthiambutene hydrochloride
    Piperidylthiambutene hydrochloride is an opioid with analgesic activity in animal models.
    Piperidylthiambutene hydrochloride
  • HY-15536B
    Cebranopadol hemicitrate
    		Agonist
    Cebranopadol hemicitrate is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively. Cebranopadol hemicitrate can be used for acute and chronic pain study.
    Cebranopadol hemicitrate
  • HY-106601
    Picenadol
    Picenadol (LY-150720) is a racemic opioid that can be used in combination with other opioids. Picenadol has anticholinergic activity.
    Picenadol
Cat. No. Product Name / Synonyms Application Reactivity
Opioid Receptor Isoform Comparison

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